iiiGatlik
High Throughput Screening Systems
High Throughput Screening Systems
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Parallel synthesis in solution is a technique used in the drug discovery to rapidly synthesize a large number of compounds. It has had a tremendous impact on the design of new drug candidates. The technique is growing in importance throughout the pharmaceutical industry because it uses the core expertise of medicinal chemists - namely, doing chemistry in solution. Gatlik offers following services: reductive and oxidative multiple synthesis and electrochemical generation of drug metabolites via a mechanism initiated by a one electron oxidation, such as N– dealkylation, S–oxidation, P–oxidation, alcohol oxidation and dehydrogenation. The benefits of reductive and oxidative parallel synthesis go beyond time saving. Although the technique can increase the output of new analogues 10-fold or more, crucially it also optimizes the discovery process. It does this by presenting chemists with a broader range of compounds, which would not have been evaluated in a traditional Quantitative Structure-Activity Relationship (QSAR) process.  |
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